dBET57

• 常用名: dBET57
• 英文名: dBET57
• CAS号: 1883863-52-2
• 分子量: 699.18
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₃₁ClN₈O₅S
• 熔点: N/A
• 闪点: N/A

dBET57用途

dBET57 是一种有效选择性的 BRD4 异源双功能降解剂,基于 PROTAC 技术,对 BRD4BD1 作用的 DC50/5h 值为 500 nM,对 BRD4BD2 不起作用。

dBET57名称

• 英文名: dBET57

dBET57生物活性

• 描述: dBET57 是一种有效选择性的 BRD4 异源双功能降解剂,基于 PROTAC 技术,对 BRD4BD1 作用的 DC50/5h 值为 500 nM,对 BRD4BD2 不起作用。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  DC50/5h: 500 nM (BRD4BD1)[1]

• 参考文献:

  [1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.

dBET57物理化学性质

• 分子式: C₃₄H₃₁ClN₈O₅S
• 分子量: 699.18
• InChIKey: CZRLOIDJCMKJHE-UXMRNZNESA-N
• SMILES: Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=NC(CC(=O)NCCNc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c1nnc(C)n1-2
• 储存条件: -20°C，密闭，干燥

dBET57靶点实验

查看更多实验

实验名称：Thermodynamic solubility of the compound in phosphate buffer at pH 7 incubated for 1 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105246

实验名称：Protac activity at BRD4 in human MM1.S cells assessed as reduction in IKZF1 protein l... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5374930

实验名称：Protac activity at BRD4 in human MOLT-4 cells assessed as reduction in IKZF3 protein ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5374931

实验名称：Protac activity at BRD4 in human MM1.S cells assessed as reduction in IKZF3 protein l... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5374929

实验名称：Protac activity at BRD4 in human MOLT-4 cells assessed as BRD4 protein degradation in... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5374922

实验名称：Protac activity at BRD4 in human MOLT-4 cells assessed as BRD4 protein degradation at... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5374920

实验名称：Plasma Protein binding in human albumin assessed as fraction bound by rapid equlibriu... 来源：ChEMBL 靶标：Albumin External Id：CHEMBL5374910

实验名称：Chromatographic hydrophobicity index, CHI of the compound at pH 7.4 by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374911

实验名称：Distribution coefficient, logD of the compound at pH 7.4 by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374909

实验名称：Protac activity at BRD4 in human MOLT-4 cells assessed as reduction in IKZF1 protein ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5374906

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