Antennapedia Peptide

Modify Date: 2024-01-09 16:09:28

Antennapedia Peptide Structure
Antennapedia Peptide structure
Common Name Antennapedia Peptide
CAS Number 188842-14-0 Molecular Weight 2246.728
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C104H168N34O20S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Antennapedia Peptide


Antennapedia Peptide is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of Cell-penetrating peptides.

 Names

Name Antennapedia Peptide
Synonym More Synonyms

 Antennapedia Peptide Biological Activity

Description Antennapedia Peptide is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of Cell-penetrating peptides.
Related Catalog
In Vitro Antennapedia (Antp)-SMCC-cytochrome c conjugate (5 μg/mL) activates caspase-dependent apoptosis of HeLa cells. The Antp-SMCC-cytochrome c conjugate reduces the clonogenic survival of Hela cells, and inhibits clonogenic survival[1]. ANTP-SmacN7 fusion protein can transduce and accumulate in cells, while SmacN7 alone cannot. ANTP-SmacN7 fusion proteins have a radiation-sensitising effect on EC109 cells. ANTP-SmacN7 combined with radiation does not promote further increases in caspase-3 protein expression, it increases the levels of cleaved caspase-3[2].
References

[1]. Imesch P, et al. Conjugates of cytochrome c and antennapedia peptide activate apoptosis and inhibit proliferation of HeLa cancer cells. Exp Ther Med. 2013 Sep;6(3):786-790. Epub 2013 Jul 4.

[2]. Du LQ, et al. Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells. Int J Mol Sci. 2013 Dec 11;14(12):24087-96.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C104H168N34O20S
Molecular Weight 2246.728
Exact Mass 2245.289551
LogP -3.11
Index of Refraction 1.670
Storage condition 2-8℃

 Synonyms

L-lysine, N5-(diaminomethylene)-L-ornithyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-N5-(diaminomethylene)-L-ornithyl-N5-(diaminomethylene)-L-ornithyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-
Penetratin
L-Lysine, L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-
Penetratin-1
L-Arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysine
N5-(diaminomethylidene)-L-ornithyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-N5-(diaminomethylidene)-L-ornithyl-N5-(diaminomethylidene)-L-ornithyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysine
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