Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)

Modify Date: 2024-01-05 12:20:56

Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid) structure	Common Name	Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)
	CAS Number	191338-87-1	Molecular Weight	506.527
	Density	1.4±0.1 g/cm3	Boiling Point	1049.7±65.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₃₀N₄O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	588.6±34.3 °C

Use of Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)

Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].

Name	ac-esmd-cho
Synonym	More Synonyms

Description	Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
References	[1]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. [2]. Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.

Description

Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase

Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

References

[1]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.

[2]. Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.

Density	1.4±0.1 g/cm3
Boiling Point	1049.7±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₀N₄O₁₀S
Molecular Weight	506.527
Flash Point	588.6±34.3 °C
Exact Mass	506.168274
PSA	253.60000
LogP	-1.68
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.555