CFTR corrector 4
Modify Date: 2024-01-12 10:18:40
CFTR corrector 4 structure
|
Common Name | CFTR corrector 4 | ||
|---|---|---|---|---|
| CAS Number | 1918142-34-3 | Molecular Weight | 539.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H27F2NO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CFTR corrector 4CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1]. |
| Name | CFTR corrector 4 |
|---|
| Description | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50:130 nM (CFTR)[1] |
| In Vitro | CFTR corrector 4 possesses high potency and efficacy with a EC50 of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log D, indicating high lipophilicity. HBE-TECC: (Human Bronchial Epithelial-Trans-Epithelial Current Clamp) assay[1]. CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC50 value 130 nM in the cell surface expression (CSE-HRP) assay[1]. |
| References |
| Molecular Formula | C29H27F2NO7 |
|---|---|
| Molecular Weight | 539.52 |