Lopinavir Metabolite M-1

Modify Date: 2024-01-09 18:40:28

Lopinavir Metabolite M-1 Structure
Lopinavir Metabolite M-1 structure
Common Name Lopinavir Metabolite M-1
CAS Number 192725-39-6 Molecular Weight 642.78400
Density N/A Boiling Point N/A
Molecular Formula C37H46N4O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lopinavir Metabolite M-1


Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].

 Names

Name Lopinavir Metabolite M-1
Synonym More Synonyms

 Lopinavir Metabolite M-1 Biological Activity

Description Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro[1][2].
Related Catalog
Target

IC50: 0.7 pM (HIV Protease)[1]

In Vitro Lopinavir Metabolite M-1 has antiviral activities in MT-4 cells, with an EC50 of 1.413 μM[1].
References

[1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.

[2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.

 Chemical & Physical Properties

Molecular Formula C37H46N4O6
Molecular Weight 642.78400
Exact Mass 642.34200
PSA 137.07000
LogP 5.63440
Index of Refraction 1.582

 Synonyms

(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2,4-dionyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane
(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-de
(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- d
4-Oxo-ABT-378
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