Lopinavir Metabolite M-1

• 常用名: Lopinavir Metabolite M-1
• 英文名: Lopinavir Metabolite M-1
• CAS号: 192725-39-6
• 分子量: 642.78400
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₇H₄₆N₄O₆
• 熔点: N/A
• 闪点: N/A

Lopinavir Metabolite M-1用途

Lopinavir Metabolite M-1 是 Lopinavir 的活性代谢产物,以 0.7 pM 的 Ki 值抑制 HIV 蛋白酶。Lopinavir Metabolite M-1 在体外具有抗病毒活性。

Lopinavir Metabolite M-1名称

• 英文名: Lopinavir Metabolite M-1

Lopinavir Metabolite M-1生物活性

• 描述: Lopinavir Metabolite M-1 是 Lopinavir 的活性代谢产物,以 0.7 pM 的 Ki 值抑制 HIV 蛋白酶。Lopinavir Metabolite M-1 在体外具有抗病毒活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶
• 靶点实验:

  IC50: 0.7 pM (HIV Protease)[1]

• 体外研究: 洛比那韦代谢产物M-1对MT-4细胞具有抗病毒活性,EC50为1.413μM[1]。
• 参考文献:

  [1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.

  [2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.

Lopinavir Metabolite M-1物理化学性质

• 分子式: C₃₇H₄₆N₄O₆
• 分子量: 642.78400
• 精确质量: 642.34200
• PSA: 137.07000
• LogP: 5.63440
• InChIKey: PSUMJBRVYHIASB-UHFFFAOYSA-N
• SMILES: Cc1cccc(C)c1OCC(=O)NC(Cc1ccccc1)C(O)CC(Cc1ccccc1)NC(=O)C(C(C)C)N1CCC(=O)NC1=O
• 折射率: 1.582

Lopinavir Metabolite M-1英文别名

• (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2,4-dionyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane
• (aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-de
• (aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-d
• 4-Oxo-ABT-378