Prosaptide Tx14(A) TFA

Modify Date: 2024-01-05 17:09:49

Prosaptide Tx14(A) TFA Structure
Prosaptide Tx14(A) TFA structure
Common Name Prosaptide Tx14(A) TFA
CAS Number 196391-82-9 Molecular Weight 1579.70
Density N/A Boiling Point N/A
Molecular Formula C69H110N16O26 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Prosaptide Tx14(A) TFA


Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

 Names

Name Prosaptide Tx14(A)

 Prosaptide Tx14(A) TFA Biological Activity

Description Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].
Related Catalog
In Vitro Prosaptide Tx14(A) promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].
References

[1]. Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534.

[2]. Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314.

 Chemical & Physical Properties

Molecular Formula C69H110N16O26
Molecular Weight 1579.70
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