Exatecan mesylate

Modify Date: 2025-08-25 19:01:06

Exatecan mesylate structure	Common Name	Exatecan mesylate
	CAS Number	197720-53-9	Molecular Weight	567.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₂FN₃O₄S_.CH₄O₃S_.2H₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Exatecan mesylate

Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1][2][3].

Name	Exatecan mesilate hydrate (JAN)
Synonym	More Synonyms

Description	Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Target	Topoisomerase I:2.2 μM (IC50)
References	[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [2]. Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5. [3]. Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6.

Molecular Formula	C₂₄H₂₂FN₃O₄S_.CH₄O₃S_.2H₂O
Molecular Weight	567.58
Exact Mass	567.16900
PSA	188.65000
LogP	3.62960
Vapour Pressure	2.47E-28mmHg at 25°C

DX-8951f

Exatecan mesylate (USAN)

UNII-D2VJ1CC26Q

Exatecan mesylate hydrate

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Exatecan mesylate

Use of Exatecan mesylate

Names

Exatecan mesylate Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.