Exatecan mesylate

• 常用名: Exatecan mesylate
• 英文名: Exatecan mesylate
• CAS号: 197720-53-9
• 分子量: 567.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₂FN₃O₄S_.CH₄O₃S_.2H₂O
• 熔点: N/A
• 闪点: N/A

Exatecan mesylate用途

Exatecan (DX-8951) mesylate dihydrate 是一种 DNA 拓扑异构酶 I (topoisomerase I) 抑制剂,IC50 值为 2.2 μM (0.975 μg/mL),可用于癌症研究。

Exatecan mesylate名称

• 英文名: Exatecan mesilate hydrate (JAN)

Exatecan mesylate生物活性

• 描述: Exatecan (DX-8951) mesylate dihydrate 是一种 DNA 拓扑异构酶 I (topoisomerase I) 抑制剂,IC50 值为 2.2 μM (0.975 μg/mL),可用于癌症研究。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
• 靶点实验:

  Topoisomerase I:2.2 μM (IC50)

• 参考文献:

  [1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

  [2]. Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5.

  [3]. Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6.

Exatecan mesylate物理化学性质

• 分子式: C₂₄H₂₂FN₃O₄S_.CH₄O₃S_.2H₂O
• 分子量: 567.58
• 精确质量: 567.16900
• PSA: 188.65000
• LogP: 3.62960
• InChIKey: FXQZOHBMBQTBMJ-MWPGLPCQSA-N
• SMILES: CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc(F)c(C)c3c1c2C(N)CC3.CS(=O)(=O)O.O.O
• 蒸汽压: 2.47E-28mmHg at 25°C

Exatecan mesylate靶点实验

查看更多实验

实验名称：Growth inhibition of human K562 cells incubated for 72 hrs by MTT assay 来源：ChEMBL 靶标：K562 External Id：CHEMBL5531510

实验名称：Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5531509

实验名称：Growth inhibition of human HCT-116 cells incubated for 72 hrs by MTT assay 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5531508

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL5531507

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

共7条，当前第1页，共1页

1

Exatecan mesylate英文别名

• DX-8951f
• Exatecan mesylate (USAN)
• UNII-D2VJ1CC26Q
• Exatecan mesylate hydrate