Medronic Acid

Modify Date: 2024-01-02 19:43:26

Medronic Acid Structure
Medronic Acid structure
Common Name Medronic Acid
CAS Number 1984-15-2 Molecular Weight 176.002
Density 2.1±0.1 g/cm3 Boiling Point 583.2±60.0 °C at 760 mmHg
Molecular Formula CH6O6P2 Melting Point 197-199 °C(lit.)
MSDS Chinese USA Flash Point 306.5±32.9 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of Medronic Acid


Medronic Acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This agent accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes in bone imaging.

 Names

Name medronic acid
Synonym More Synonyms

 Medronic Acid Biological Activity

Description Medronic Acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This agent accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes in bone imaging.
Related Catalog
References

[1]. Ohta Y, et al. Salt Tolerance Enhancement of Liquid Chromatography-Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Using Matrix Additive MethylenediphosphonicAcid. Mass Spectrom (Tokyo). 2014;3(1):A0031.

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 583.2±60.0 °C at 760 mmHg
Melting Point 197-199 °C(lit.)
Molecular Formula CH6O6P2
Molecular Weight 176.002
Flash Point 306.5±32.9 °C
Exact Mass 175.963959
PSA 134.68000
LogP -4.11
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.550
Storage condition 2-8°C

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C: Corrosive;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3261 8/PG 3
WGK Germany -
RTECS SZ9138000
Packaging Group III
Hazard Class 8
HS Code 2931900090

 Synthetic Route

~97%

Medronic Acid Structure

Medronic Acid

CAS#:1984-15-2

Literature: Rubino, Maria Teresa; Agamennone, Mariangela; Campestre, Cristina; Campiglia, Pietro; Cremasco, Viviana; Faccio, Roberta; Laghezza, Antonio; Loiodice, Fulvio; Maggi, Dariana; Panza, Emilia; Rossello, Armando; Tortorella, Paolo ChemMedChem, 2011 , vol. 6, # 7 p. 1258 - 1268

~93%

Medronic Acid Structure

Medronic Acid

CAS#:1984-15-2

Literature: Bulman Page, Philip C.; McKenzie, Michael J.; Gallagher, James A. Synthetic Communications, 2002 , vol. 32, # 2 p. 211 - 218

~99%

Medronic Acid Structure

Medronic Acid

CAS#:1984-15-2

Literature: Mohamady, Samy; Jakeman, David L. Journal of Organic Chemistry, 2005 , vol. 70, # 25 p. 10588 - 10591

~%

Medronic Acid Structure

Medronic Acid

CAS#:1984-15-2

Literature: Journal of the American Chemical Society, , vol. 83, p. 1722 - 1726

~%

Medronic Acid Structure

Medronic Acid

CAS#:1984-15-2

Literature: Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, , vol. 31, p. 153 - 157

~%

Medronic Acid Structure

Medronic Acid

CAS#:1984-15-2

Literature: Phosphorus, Sulfur and Silicon and Related Elements, , vol. 161, p. 75 - 96

 Customs

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

MDP,Medronic acid
phosphonomethylphosphonic acid
MDP,Medronic acid,Methylenediphosphonic acid
methanediylbis(phosphonic acid)
MDP~Medronicacid
Medronic Acid
Methylenediphosphonic acid
Methylenebiphosphonic Acid
methylene biphosphonate
acide méthanediylbis(phosphonique)
Methanebisphosphonic Acid
Methanediphosphonic Acid
Medronic acid [USAN:BAN:INN]
METHYLENEBISPHOSPHONIC ACID
Medronic
methylenediphosphonate
Phosphonic acid, methylenebis-
EINECS 217-851-0
MDP
Methylenebis(phosphonic acid)
MFCD00002139
Methandiylbis(phosphonsäure)
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