CRK12-IN-2
Modify Date: 2024-07-18 18:12:16
CRK12-IN-2 structure
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Common Name | CRK12-IN-2 | ||
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| CAS Number | 1990479-17-8 | Molecular Weight | 529.67 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H33F2N5O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CRK12-IN-2CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis[1]. |
| Name | CRK12-IN-2 |
|---|
| Description | CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis[1]. |
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| Related Catalog | |
| In Vivo | CRK12-IN-2 (10 mg/kg; s.c. once daily for 4 days) effectively cures mice with T. congolense- and T. vivax-infection[1]. 1.19Pharmacokinetic Properties of CRK12-IN-2 in Cattle[1]. Cattle IV 2 mg/kg Cattle IM 10 mg/kg Clb (mL/min/kg) 15±5 Vdss (L/kg) 2.3±0.6 half-life (h) 4±2 AUC0-∞(ng·min/mL) 140000±40000 500000±30000 Cmax (ng/mL) 1700±800 Tmax (h) 1.3±0.6 F (%) 73±6 Animal Model: Mice with T. congolense and T. vivax infection[1] Dosage: 10 mg/kg Administration: Subcutaneous injection; 10 mg/kg once daily; for 4 days Result: Fully cured both T. congolense- and T. vivax-infected mice for 4 days at a dose of 10 mg/kg. |
| References |
| Molecular Formula | C23H33F2N5O3S2 |
|---|---|
| Molecular Weight | 529.67 |