Flumethasone 21-pivalate

Modify Date: 2024-01-04 19:24:31

Flumethasone 21-pivalate Structure
Flumethasone 21-pivalate structure
Common Name Flumethasone 21-pivalate
CAS Number 2002-29-1 Molecular Weight 494.56800
Density 1.27g/cm3 Boiling Point 600.3ºC at 760mmHg
Molecular Formula C27H36F2O6 Melting Point N/A
MSDS Chinese USA Flash Point 316.8ºC
Symbol GHS08
GHS08
Signal Word Warning

 Use of Flumethasone 21-pivalate


Flumethasone pivalate is a glucocorticoid corticosteroid and a corticosteroid ester. Flumetasone pivalate has anti-inflammatory, antipruritic, and vasoconstrictive activities[1].

 Names

Name flumethasone pivalate
Synonym More Synonyms

 Flumethasone 21-pivalate Biological Activity

Description Flumethasone pivalate is a glucocorticoid corticosteroid and a corticosteroid ester. Flumetasone pivalate has anti-inflammatory, antipruritic, and vasoconstrictive activities[1].
Related Catalog
References

[1]. Mandour, A.A., et al. Review on analytical studies of some pharmaceutical compounds containing heterocyclic rings: brinzolamide, timolol maleate, flumethasone pivalate, and clioquinol. Futur J Pharm Sci 6, 52 (2020).

 Chemical & Physical Properties

Density 1.27g/cm3
Boiling Point 600.3ºC at 760mmHg
Molecular Formula C27H36F2O6
Molecular Weight 494.56800
Flash Point 316.8ºC
Exact Mass 494.24800
PSA 100.90000
LogP 3.44070
Vapour Pressure 6.51E-17mmHg at 25°C
Index of Refraction 1.55

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3832010
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-, 21-pivalate
CAS REGISTRY NUMBER :
2002-29-1
LAST UPDATED :
199710
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C27-H36-F2-O6
MOLECULAR WEIGHT :
494.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P280
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful;
Risk Phrases R40
Safety Phrases S22-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TU3832010

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

MFCD00079287
Flumethasone pivalate
Flumethasone 21-Pivalate
[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate
EINECS 217-901-1
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