Vilanterol-d4 (triphenylacetate)

Modify Date: 2024-01-09 20:27:42

Vilanterol-d4 (triphenylacetate) structure	Common Name	Vilanterol-d4 (triphenylacetate)
	CAS Number	2021249-10-3	Molecular Weight	778.79
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₄H₄₅D₄Cl₂NO₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Vilanterol-d4 (triphenylacetate)

Vilanterol-d4 (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.

Name	Vilanterol-d4 (triphenylacetate)
Synonym	More Synonyms

Description	Vilanterol-d4 (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Slack RJ, et al. In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action. J Pharmacol Exp Ther. 2013 Jan;344(1):218-30 [3]. Kempsford R, et al. Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD. Pulm Pharmacol Ther. 2013 Apr;26(2):256- [4]. Harrell AW, et al. Metabolism and disposition of Vilanterol, a long-acting β(2)-adrenoceptor agonist for inhalation use in humans. Drug Metab Dispos. 2013 Jan;41(1):89-100.

Molecular Formula	C₄₄H₄₅D₄Cl₂NO₇
Molecular Weight	778.79
Exact Mass	777.313721

Triphenylacetic acid - 4-[(1R)-2-{[6-({2-[(2,6-dichlorobenzyl)oxy](2H4)ethyl}oxy)hexyl]amino}-1-hydroxyethyl]-2-(hydroxymethyl)phenol (1:1)

Benzeneacetic acid, α,α-diphenyl-, compd. with (α1R)-α1-[[[6-[[2-[(2,6-dichlorophenyl)methoxy]ethyl-1,1,2,2-d4]oxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol (1:1)

Vilanterol-d4 (triphenylacetate)

Vilanterol-d4 (triphenylacetate)

Use of Vilanterol-d4 (triphenylacetate)

Names

Vilanterol-d4 (triphenylacetate) Biological Activity

Chemical & Physical Properties

Synonyms