Rbin-2

Modify Date: 2024-01-13 16:36:53

Rbin-2 Structure
Rbin-2 structure
Common Name Rbin-2
CAS Number 2032282-97-4 Molecular Weight 335.22
Density 1.6±0.1 g/cm3 Boiling Point 524.3±60.0 °C at 760 mmHg
Molecular Formula C13H11BrN4S Melting Point N/A
MSDS N/A Flash Point 270.9±32.9 °C

 Use of Rbin-2


Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1].

 Names

Name Rbin-2
Synonym More Synonyms

 Rbin-2 Biological Activity

Description Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1].
Related Catalog
References

[1]. Kawashima SA, et al. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 524.3±60.0 °C at 760 mmHg
Molecular Formula C13H11BrN4S
Molecular Weight 335.22
Flash Point 270.9±32.9 °C
Exact Mass 333.988770
LogP 4.05
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.750

 Synonyms

7-Bromo-2-(2-methyl-allylsulfanyl)-9H-1,3,4,9-tetraaza-fluorene
5H-1,2,4-Triazino[5,6-b]indole, 7-bromo-3-[(2-methyl-2-propen-1-yl)thio]-
Rbin-2
7-Bromo-3-[(2-methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
7-Bromo-3-[(2-methyl-2-propen-1-yl)thio]-5H-1,2,4-Triazino[5,6-b]indole