BC-1485

Modify Date: 2024-04-02 11:25:04

BC-1485 Structure
BC-1485 structure
 Common Name BC-1485
CAS Number 2035085-19-7 Molecular Weight 431.467
Density N/A Boiling Point N/A
Molecular Formula C19H21N5O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BC-1485


BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination; exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480; dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells; ameliorates fibrosis in murine models.

 Names

Name BC-1485

 BC-1485 Biological Activity

Description BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination; exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480; dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells; ameliorates fibrosis in murine models.
References References 1. Lear T, et al. J Exp Med. 2016 May 30;213(6):1029-46. 2. Lear T, et al. Cytokine. 2016 Dec;88:193-195. View Related Products by Target E3 Ubiquitin Ligase

 Chemical & Physical Properties

Molecular Formula C19H21N5O5S
Molecular Weight 431.467
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Chemsrc provides BC-1485(CAS#:2035085-19-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BC-1485 are included as well.>> amp version: BC-1485

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