BC-23

Modify Date: 2024-01-12 21:49:44

BC-23 structure	Common Name	BC-23
	CAS Number	6298-15-3	Molecular Weight	439.87
	Density	1.56g/cm3	Boiling Point	615.9ºC at 760mmHg
	Molecular Formula	C₂₁H₁₄ClN₃O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	326.3ºC

Use of BC-23

BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2].

Name	3--2-chlor-1.4-naphthochinon

Description	BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. [2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407.

Description

BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

References

[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92.

[2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407.

Density	1.56g/cm3
Boiling Point	615.9ºC at 760mmHg
Molecular Formula	C₂₁H₁₄ClN₃O₄S
Molecular Weight	439.87
Flash Point	326.3ºC
Exact Mass	439.03900
PSA	113.61000
LogP	5.05070
Index of Refraction	1.721

2,3-Dichlor-1,4...

CAS#:117-80-6

Sulfapyridine

CAS#:144-83-2

~53%

BC-23

CAS#:6298-15-3

Literature: Lawrence, Harshani R.; Kazi, Aslamuzzaman; Luo, Yunting; Kendig, Robert; Ge, Yiyu; Jain, Sanjula; Daniel, Kenyon; Santiago, Daniel; Guida, Wayne C.; Sebti, Said M. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5576 - 5592

2,3-Dichlor-1,4...

CAS#:117-80-6

Sulfapyridine

CAS#:144-83-2

N,N-Diethylaniline

CAS#:91-66-7

BC-23

CAS#:6298-15-3

Literature: Calandra; Adams Journal of the American Chemical Society, 1950 , vol. 72, p. 4804

Precursor 3
CAS#:117-80-6 2,3-Dichlor-1,4... CAS#:144-83-2 Sulfapyridine CAS#:91-66-7 N,N-Diethylaniline
DownStream 0

DC Chemicals Limited
China
Product Name: BC-23
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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