Salcaprozate sodium
Modify Date: 2024-01-03 16:08:14
Salcaprozate sodium structure
|
Common Name | Salcaprozate sodium | ||
|---|---|---|---|---|
| CAS Number | 203787-91-1 | Molecular Weight | 301.313 | |
| Density | N/A | Boiling Point | 521.7ºC at 760 mmHg | |
| Molecular Formula | C15H20NNaO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 269.3ºC | |
Use of Salcaprozate sodiumSalcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2]. |
| Name | Salcaprozate sodium |
|---|---|
| Synonym | More Synonyms |
| Description | Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL[3]. SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution[3]. |
| In Vivo | SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats[3]. SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident[1]. SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d[1]. Animal Model: Sprague-Dawley rats (6-7 weeks)[1] Dosage: 2000 mg/kg/d Administration: Oral gavage for 13 weeks Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d. |
| References |
| Boiling Point | 521.7ºC at 760 mmHg |
|---|---|
| Molecular Formula | C15H20NNaO4 |
| Molecular Weight | 301.313 |
| Flash Point | 269.3ºC |
| Exact Mass | 301.128998 |
| PSA | 89.46000 |
| LogP | 1.60340 |
| Vapour Pressure | 1.03E-11mmHg at 25°C |
| Sodium 8-[(2-hydroxybenzoyl)amino]octanoate |
| E414 |
| Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, sodium salt (1:1) |
| Salcaprozate sodium |
| SNAC |