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203787-91-1

203787-91-1 structure
203787-91-1 structure
  • Name: Salcaprozate sodium
  • Chemical Name: Salcaprozate sodium
  • CAS Number: 203787-91-1
  • Molecular Formula: C15H20NNaO4
  • Molecular Weight: 301.313
  • Catalog: Research Areas Others
  • Create Date: 2018-12-02 15:39:57
  • Modify Date: 2024-01-03 16:08:14
  • Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].
Name Salcaprozate sodium
Synonyms Sodium 8-[(2-hydroxybenzoyl)amino]octanoate
E414
Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, sodium salt (1:1)
Salcaprozate sodium
SNAC
Description Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].
Related Catalog
In Vitro SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL[3]. SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution[3].
In Vivo SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats[3]. SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident[1]. SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d[1]. Animal Model: Sprague-Dawley rats (6-7 weeks)[1] Dosage: 2000 mg/kg/d Administration: Oral gavage for 13 weeks Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.
References

[1]. Riley MGI, et, al. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats. Int J Toxicol. Jul-Aug 2009; 28(4):278-93.

[2]. Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10). Pharmaceutics. 2019 Feb 13; 11(2):78.

[3]. Li Y, et, al. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules. 2018 Nov 16; 23(11):2990.
Boiling Point 521.7ºC at 760 mmHg
Molecular Formula C15H20NNaO4
Molecular Weight 301.313
Flash Point 269.3ºC
Exact Mass 301.128998
PSA 89.46000
LogP 1.60340
Vapour Pressure 1.03E-11mmHg at 25°C

Chemsrc provides CAS#:203787-91-1 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 203787-91-1 | Chemsrc address: https://m.chemsrc.com/en/baike/561287.html

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