PG-S3-001
Modify Date: 2025-09-27 12:40:26
PG-S3-001 structure
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Common Name | PG-S3-001 | ||
|---|---|---|---|---|
| CAS Number | 2047372-50-7 | Molecular Weight | 652.677 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H33F5N2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PG-S3-001PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts. |
| Name | PG-S3-001 |
|---|
| Description | PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts. |
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| References | References 1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805. View Related Products by Target STAT |
| Molecular Formula | C32H33F5N2O5S |
|---|---|
| Molecular Weight | 652.677 |
| InChIKey | XZTNTXYTMCVENR-UHFFFAOYSA-N |
| SMILES | CC(C)C(C(=O)N(Cc1ccc(C2CCCCC2)cc1)c1ccc(C(=O)O)cc1)N(C)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |