Azido-PEG4-Val-Cit-PAB-OH

Modify Date: 2025-09-21 13:05:47

Azido-PEG4-Val-Cit-PAB-OH Structure
Azido-PEG4-Val-Cit-PAB-OH structure
Common Name Azido-PEG4-Val-Cit-PAB-OH
CAS Number 2055024-64-9 Molecular Weight 652.74
Density N/A Boiling Point N/A
Molecular Formula C29H48N8O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azido-PEG4-Val-Cit-PAB-OH


Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

 Names

Name Azido-PEG4-Val-Cit-PAB-OH

 Azido-PEG4-Val-Cit-PAB-OH Biological Activity

Description Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog
Target

PEGs

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32.

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C29H48N8O9
Molecular Weight 652.74
Storage condition 2-8°C
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