Hexokinase 2 modulator Comp-1
Modify Date: 2023-01-14 18:17:57
Hexokinase 2 modulator Comp-1 structure
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Common Name | Hexokinase 2 modulator Comp-1 | ||
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| CAS Number | 2055404-90-3 | Molecular Weight | 337.419 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Hexokinase 2 modulator Comp-1Tuvatexib (Hexokinase 2 modulator Comp-1) is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM; does not affect the VDAC1/HK1 complex; dose-dependent reduces mitochondrial-bound HK2 levels in human skin SCC A431 cells with IC50 of 0.8 uM, reduces glycolysis and triggers apoptosis in cancer cells, without affecting hexokinase 1-expressing normal cells; demonstrates anti-cancer activity in UVB-damaged skin model in SKH-1 mice. |
| Name | Tuvatexib |
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| Description | Tuvatexib (Hexokinase 2 modulator Comp-1) is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM; does not affect the VDAC1/HK1 complex; dose-dependent reduces mitochondrial-bound HK2 levels in human skin SCC A431 cells with IC50 of 0.8 uM, reduces glycolysis and triggers apoptosis in cancer cells, without affecting hexokinase 1-expressing normal cells; demonstrates anti-cancer activity in UVB-damaged skin model in SKH-1 mice. |
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| References | References 1. Behar V, et al. J Invest Dermatol. 2018 Jun 14. pii: S0022-202X(18)32056-6. 2. Goldin N, et al. Oncogene. 2008 Aug 7;27(34):4636-43. 3. Krasnov GS, et al. Expert Opin Ther Targets. 2013 Oct;17(10):1221-33. 4. PCT Int. Appl. (2018), WO 2018083705 A1 20180511. View Related Products by Target Hexokinase |
| Molecular Formula | C21H23NO3 |
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| Molecular Weight | 337.419 |