Ergosterol endoperoxide

Modify Date: 2024-01-02 12:18:44

Ergosterol endoperoxide structure	Common Name	Ergosterol endoperoxide
	CAS Number	2061-64-5	Molecular Weight	428.647
	Density	1.1±0.1 g/cm3	Boiling Point	499.7±45.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₄₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	256.0±28.7 °C

Use of Ergosterol endoperoxide

Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities[1][2].

Name	ergosterol peroxide
Synonym	More Synonyms

Description	Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Ming Bu, et al. Synthesis of Ergosterol Peroxide Conjugates as Mitochondria Targeting Probes for Enhanced Anticancer Activity. Molecules. 2019 Sep 11;24(18):3307 [2]. Taotao Ling, et al. Development of ergosterol peroxide probes for cellular localisation studies. Org Biomol Chem. 2019 May 29;17(21):5223-5229.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Ming Bu, et al. Synthesis of Ergosterol Peroxide Conjugates as Mitochondria Targeting Probes for Enhanced Anticancer Activity. Molecules. 2019 Sep 11;24(18):3307

[2]. Taotao Ling, et al. Development of ergosterol peroxide probes for cellular localisation studies. Org Biomol Chem. 2019 May 29;17(21):5223-5229.

Density	1.1±0.1 g/cm3
Boiling Point	499.7±45.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.647
Flash Point	256.0±28.7 °C
Exact Mass	428.329041
PSA	38.69000
LogP	7.68
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.552

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE7289000

CHEMICAL NAME :: 5-alpha,8-alpha-Ergosta-6,22-dien-3-beta-ol, 5,8-epidioxy-

CAS REGISTRY NUMBER :: 2061-64-5

BEILSTEIN REFERENCE NO. :: 0096852

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C28-H44-O3

MOLECULAR WEIGHT :: 428.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 46,461,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: female 6-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 46,461,1976

Hazard Codes	Xi

Precursor 0
DownStream 1
CAS#:60045-90-1 (3β,6α,9ξ,14ξ,2...

5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol

Ergosterol peroxide

Peroxyergosterol

(3S,5S,8S,9R,10R,13R,14R,17R)-17-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-1,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-2H-5,8-epidioxycyclopenta[a]phenanthren-3-ol

3b,5a-Etheno-1H-benz[c]indeno[5,4-e][1,2]dioxin-7-ol, 2,3,3a,6,7,8,9,9a,9b,10,11,11a-dodecahydro-9a,11a-dimethyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-, (1R,3aR,3bS,5aS,7S,9aR,9bR,11aR)-

UNII:UG9TN81TGH

Ergosterol endoperoxide

(1S,2R,5R,6R,9R,10R,13S,15S)-5-[(2R,3E,5R)-5,6-Dimethyl-3-hepten-2-yl]-6,10-dimethyl-16,17-dioxapentacyclo[13.2.2.0.0.0]nonadec-18-en-13-ol

Ergosterol 5.alpha.,8.alpha.-epidioxide

Ergosterol 5.α.,8.α.-epidioxide

ergosterol-5,8-peroxide

5α,8α-Ergosta-6,22-dien-3β-ol, 5,8-epidioxy-