MAP4K4-IN-37
Modify Date: 2024-04-02 11:38:37
MAP4K4-IN-37 structure
|
Common Name | MAP4K4-IN-37 | ||
|---|---|---|---|---|
| CAS Number | 2089334-01-8 | Molecular Weight | 382.844 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19ClN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MAP4K4-IN-37MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice |
| Name | MAP4K4-IN-37 |
|---|
| Description | MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice |
|---|---|
| References | References 1. Dow RL, et al. J Med Chem. 2018 Apr 12;61(7):3114-3125. View Related Products by Target MAP4K |
| Molecular Formula | C21H19ClN2O3 |
|---|---|
| Molecular Weight | 382.844 |