eIF4A3 inhibitor 53a
Modify Date: 2025-09-11 09:47:50
eIF4A3 inhibitor 53a structure
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Common Name | eIF4A3 inhibitor 53a | ||
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| CAS Number | 2095486-67-0 | Molecular Weight | 588.88 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H23BrClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of eIF4A3 inhibitor 53aeIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1]. |
| Name | eIF4A3-IN-1 |
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| Description | eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1]. |
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| Related Catalog | |
| Target |
IC50: 0.2 μM (eIF4A3)[1] Kd: 0.043 μM (eIF4A3)[1] |
| References |
| Molecular Formula | C29H23BrClN5O2 |
|---|---|
| Molecular Weight | 588.88 |