AT-121

Modify Date: 2025-08-26 11:06:09

AT-121 Structure
AT-121 structure
Common Name AT-121
CAS Number 2099681-31-7 Molecular Weight 462.65
Density N/A Boiling Point N/A
Molecular Formula C24H38N4O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AT-121


AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].

 Names

Name AT-121

 AT-121 Biological Activity

Description AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].
Related Catalog
In Vivo AT-121 (0.003-0.03 mg/kg; s.c.) produces potent antinociceptive effect[1]. Animal Model: Adult male and female rhesus monkeys[1] Dosage: 0.003-0.03 mg/kg Administration: Subcutaneous Result: Produced antinociceptive effects against an acute noxious stimulus, 50 °C water, in a dose-dependent.
References

[1]. Ding H, Kiguchi N, Yasuda D, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10(456):eaar3483. doi:10.1126/scitranslmed.aar3483

 Chemical & Physical Properties

Molecular Formula C24H38N4O3S
Molecular Weight 462.65
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