Angoline
Modify Date: 2025-08-27 09:01:28
Angoline structure
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Common Name | Angoline | ||
|---|---|---|---|---|
| CAS Number | 21080-31-9 | Molecular Weight | 379.40600 | |
| Density | 1.36g/cm3 | Boiling Point | 555.5ºC at 760 mmHg | |
| Molecular Formula | C22H21NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 164.1ºC | |
Use of AngolineAngoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. |
| Name | 1,2,13-trimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine |
|---|---|
| Synonym | More Synonyms |
| Description | Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. |
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| Related Catalog | |
| Target |
IC50: 11.56 μM (IL6/STAT3 signaling pathway) |
| References |
| Density | 1.36g/cm3 |
|---|---|
| Boiling Point | 555.5ºC at 760 mmHg |
| Molecular Formula | C22H21NO5 |
| Molecular Weight | 379.40600 |
| Flash Point | 164.1ºC |
| Exact Mass | 379.14200 |
| PSA | 49.39000 |
| LogP | 4.41250 |
| Vapour Pressure | 2.23E-12mmHg at 25°C |
| Index of Refraction | 1.678 |
| Hazard Codes | Xi |
|---|
|
~92%
Angoline CAS#:21080-31-9 |
| Literature: Miao, Fang; Yang, Xin-Juan; Ma, Yan-Ni; Zheng, Feng; Song, Xiao-Ping; Zhou, Le Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1508 - 1513 |
|
~%
Angoline CAS#:21080-31-9 |
| Literature: Hanaoka, Miyoji; Motonishi, Toshio; Mukai, Chisato Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 2253 - 2256 |
|
~95%
Angoline CAS#:21080-31-9 |
| Literature: Hanaoka, Miyoji; Motonishi, Toshio; Mukai, Chisato Journal of the Chemical Society, Chemical Communications, 1984 , # 11 p. 718 - 719 |
|
~44%
Angoline CAS#:21080-31-9 |
| Literature: Miao, Fang; Yang, Xin-Juan; Zhou, Le; Hu, Hai-Jun; Zheng, Feng; Ding, Xu-Dong; Sun, Dong-Mei; Zhou, Chun-Dong; Sun, Wei Natural Product Research, 2011 , vol. 25, # 9 p. 863 - 875 |
| 12,13-dihydro-13-methoxychelerythrine |
| 8-methoxydihydrochelerythrine |
| Angoline |
| 6-methoxy-5,6-dihydrochelerythrine |