21080-31-9
21080-31-9 structure
- Name: Angoline
- Chemical Name: 1,2,13-trimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
- CAS Number: 21080-31-9
- Molecular Formula: C22H21NO5
- Molecular Weight: 379.40600
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2017-01-11 15:16:24
- Modify Date: 2026-08-23 18:12:03
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Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
| Name | 1,2,13-trimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine |
|---|---|
| Synonyms |
6-methoxy-5,6-dihydrochelerythrine
Angoline, 10 mM in DMSO 1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine 12,13-dihydro-13-methoxychelerythrine 8-methoxydihydrochelerythrine phosphorylation,proliferation,STAT3,anticancer,inhibit,Angoline,Inhibitor,STAT,IL-6 [1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2,13-trimethoxy-12-methyl angoline 12,13-Dihydro-1,2,13-trimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine 6-Methoxyldihydrochelerythrine 6-Methoxydihydrocheleryth |
| Description | Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 11.56 μM (IL6/STAT3 signaling pathway) |
| References |
| Density | 1.36g/cm3 |
|---|---|
| Boiling Point | 555.5ºC at 760 mmHg |
| Molecular Formula | C22H21NO5 |
| Molecular Weight | 379.40600 |
| Flash Point | 164.1ºC |
| Exact Mass | 379.14200 |
| PSA | 49.39000 |
| LogP | 4.41250 |
| Vapour Pressure | 2.23E-12mmHg at 25°C |
| Index of Refraction | 1.678 |
| Hazard Codes | Xi |
|---|
| Precursor 5 | |
|---|---|
| DownStream 0 | |