21080-31-9

21080-31-9 structure

Name: Angoline
Chemical Name: 1,2,13-trimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
CAS Number: 21080-31-9
Molecular Formula: C₂₂H₂₁NO₅
Molecular Weight: 379.40600
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2017-01-11 15:16:24
Modify Date: 2025-08-27 09:01:28
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

Name	1,2,13-trimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
Synonyms	12,13-dihydro-13-methoxychelerythrine 8-methoxydihydrochelerythrine Angoline 6-methoxy-5,6-dihydrochelerythrine

Description	Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	IC50: 11.56 μM (IL6/STAT3 signaling pathway)
References	[1]. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

Hazard Codes	Xi

67-56-1

3895-92-9

~92%

21080-31-9

28342-33-8

21080-31-9

67-56-1

4070-42-2

~95%

21080-31-9

Literature: Hanaoka, Miyoji; Motonishi, Toshio; Mukai, Chisato Journal of the Chemical Society, Chemical Communications, 1984 , # 11 p. 718 - 719

124-41-4

34316-15-9

~44%

21080-31-9