Pa 155A

Modify Date: 2024-01-05 10:18:42

Pa 155A Structure
Pa 155A structure
Common Name Pa 155A
CAS Number 21200-24-8 Molecular Weight 257.288
Density 1.4±0.1 g/cm3 Boiling Point 420.8±37.0 °C at 760 mmHg
Molecular Formula C14H15N3O2 Melting Point N/A
MSDS N/A Flash Point 208.3±26.5 °C

 Use of Pa 155A


Indolmycin (TAK-083), an antibiotic, is a competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase (TrpS). Indolmycin (TAK-083) possesses both anti-viral and anti-bacterial activity[1][2][3].

 Names

Name indolmycin
Synonym More Synonyms

 Pa 155A Biological Activity

Description Indolmycin (TAK-083), an antibiotic, is a competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase (TrpS). Indolmycin (TAK-083) possesses both anti-viral and anti-bacterial activity[1][2][3].
Related Catalog
In Vitro Indolmycin was bacteriostatic and demonstrated good activity against MSSA (methicillinsusceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycinintermediate S. aureus), including strains resistant to mupirocin or fusidic acid. Indolmycin MICs for 20 strains ranged from 8 to 32 mg/L, whereas asingle strain exhibited high-level resistance (MIC 128 mg/L)[2].
References

[1]. R G Werner, et al. Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase. Eur J Biochem. 1976 Sep;68(1):1-3.

[2]. Julian G Hurdle, et al. Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. J Antimicrob Chemother. 2004 Aug;54(2):549-52.

[3]. M R Harnden, et al. Thiazolinone analogues of indolmycin with antiviral and antibacterial activity. J Med Chem. 1978 Jan;21(1):82-7.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 420.8±37.0 °C at 760 mmHg
Molecular Formula C14H15N3O2
Molecular Weight 257.288
Flash Point 208.3±26.5 °C
Exact Mass 257.116425
PSA 69.97000
LogP 1.53
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.670

 Safety Information

HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

[S-(R*,S*)]-5-[1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-4(5H)-oxazolone
(1R,5S)-(-)-5-(1-Indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one
(5S)-5-[(1R)-1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4(5H)-one
Indolemycin
4(5H)-Oxazolone, 5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-, (5S)-
2-Methylamino-5a-(b-indolyl)ethyl-2-oxazolin-4-one
Pa 155A
indolmycin
2-Oxazolin-4-one,5-(1-indol-3-ylethyl)-2-(methylamino)-,(1R,5S)-(-)
4(5H)-Oxazolone,5-(1-(1H-indol-3-yl)ethyl)-2-(methylamino)-,(S-(R*,S*))
PA 155 A
5-(1-Indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one
Indomycin
(5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one
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