WNK-IN-11

Modify Date: 2024-01-10 17:44:55

WNK-IN-11 Structure
WNK-IN-11 structure
Common Name WNK-IN-11
CAS Number 2123489-30-3 Molecular Weight 462.4
Density N/A Boiling Point N/A
Molecular Formula C21H21Cl2N5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WNK-IN-11


WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.

 Names

Name WNK-IN-11

 WNK-IN-11 Biological Activity

Description WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.
Related Catalog
Target

IC50: 4 nM (WNK1)[1].

In Vitro WNK-IN-11 (compound 11) shows IC50<2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket[1].
References

[1]. Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107.

 Chemical & Physical Properties

Molecular Formula C21H21Cl2N5OS
Molecular Weight 462.4
Storage condition -20℃
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Price: ¥3850/10 mM * 1 mL in DMSO

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