AKR1C3-IN-6

Modify Date: 2025-08-27 13:43:03

AKR1C3-IN-6 structure	Common Name	AKR1C3-IN-6
	CAS Number	2137881-54-8	Molecular Weight	392.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₅F₃N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AKR1C3-IN-6

AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity[1].

Name	AKR1C3-IN-6

Description	AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.31 μM (AKR1C3), 73.23 μM (AKR1C2)[1]
In Vitro	AKR1C3-IN-6 (Compound 1) shows antiproliferative activity with an IC50 of 81.40 ± 2.29 μM against prostate cancer cell line 22rv1[1].
References	[1]. Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366.

Molecular Formula	C₁₈H₁₅F₃N₄O₃
Molecular Weight	392.33

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