H-Arg(NO2)-OH
H-Arg(NO2)-OH structure
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Common Name | H-Arg(NO2)-OH | ||
|---|---|---|---|---|
| CAS Number | 2149-70-4 | Molecular Weight | 219.199 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 462.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C6H13N5O4 | Melting Point | 257 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 233.5±31.5 °C | |
Use of H-Arg(NO2)-OHNitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects. Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine. Nitroarginine is currently in clinical trials for treating patients with advanced solid tumors. |
| Name | N'-Nitro-L-arginine |
|---|---|
| Synonym | More Synonyms |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 462.4±55.0 °C at 760 mmHg |
| Melting Point | 257 °C (dec.)(lit.) |
| Molecular Formula | C6H13N5O4 |
| Molecular Weight | 219.199 |
| Flash Point | 233.5±31.5 °C |
| Exact Mass | 219.096756 |
| PSA | 157.05000 |
| LogP | -0.79 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.638 |
| InChIKey | MRAUNPAHJZDYCK-BYPYZUCNSA-N |
| SMILES | NC(=NCCCC(N)C(=O)O)N[N+](=O)[O-] |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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H-Arg(NO2)-OH CAS#:2149-70-4 |
| Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 224, p. 40,43 |
|
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H-Arg(NO2)-OH CAS#:2149-70-4 |
| Literature: Justus Liebigs Annalen der Chemie, , vol. 642, p. 145 - 162 |
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H-Arg(NO2)-OH CAS#:2149-70-4 |
| Literature: Chemische Berichte, , vol. 97, p. 3312 - 3316 Bulletin of the Chemical Society of Japan, , vol. 38, p. 1148 - 1157 |
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H-Arg(NO2)-OH CAS#:2149-70-4 |
| Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 72, p. 489 |
| Precursor 4 | |
|---|---|
| DownStream 10 | |
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Evidence for the gastric cytoprotective effect of centrally injected agmatine.
Brain Res. Bull. 108 , 51-9, (2014) Agmatine (decarboxylated arginine) exerts cytoprotective action in several tissues, such as in the brain, heart or kidneys, but there is still controversy over the effects of agmatine on the gastric m... |
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Name: qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali...
Source: NCGC
External Id: adst_MBL_Abs_LOPAC_o1
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Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2...
Source: NCGC
Target: ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens]
External Id: UBCH001
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Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Inhibition of human DDAH1 at 1 mM by HPLC
Source: ChEMBL
Target: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
External Id: CHEMBL1020493
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Name: Selectivity ratio of Ki for bovine eNOS to Ki for rat nNOS
Source: ChEMBL
Target: N/A
External Id: CHEMBL2343337
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| (S)-2-Amino-5-(3-nitroguanidino)pentanoic acid |
| ARG(NO2) |
| L-NNA |
| N-ω-NITRO-L-ARGININE |
| L-NOARG |
| Nω-Nitro-L-arginine |
| (S)-2-Aminobut-3-enoic acid |
| H-Arg(NO2)-OH |
| H-ARG(NO2)-OME |
| Nω-Nitro-L-arginine (L-NNA) |
| NG-nitro-L-arginine |
| EINECS 218-418-9 |
| MFCD00007033 |
| NG-NO2-L-ARG |
| L-NA,L-NNA |
| L-NA |
| L-NO2ARG |
| nitroarginine |
| Nomega-nitro-L-arginine |
| L-NNA N5-(Nitroamidino)-L-2,5-diaminopentanoic acid NG-NO2-L-Arg |
| L-NG-nitroarginine |
| N-(N-Nitrocarbamimidoyl)-L-ornithine |