H-Arg(NO2)-OH

Modify Date: 2024-01-02 19:43:19

H-Arg(NO2)-OH Structure
H-Arg(NO2)-OH structure
Common Name H-Arg(NO2)-OH
CAS Number 2149-70-4 Molecular Weight 219.199
Density 1.7±0.1 g/cm3 Boiling Point 462.4±55.0 °C at 760 mmHg
Molecular Formula C6H13N5O4 Melting Point 257 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 233.5±31.5 °C

 Use of H-Arg(NO2)-OH


Nitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects. Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine. Nitroarginine is currently in clinical trials for treating patients with advanced solid tumors.

 Names

Name N'-Nitro-L-arginine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 462.4±55.0 °C at 760 mmHg
Melting Point 257 °C (dec.)(lit.)
Molecular Formula C6H13N5O4
Molecular Weight 219.199
Flash Point 233.5±31.5 °C
Exact Mass 219.096756
PSA 157.05000
LogP -0.79
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.638

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

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H-Arg(NO2)-OH Structure

H-Arg(NO2)-OH

CAS#:2149-70-4

Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 224, p. 40,43

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H-Arg(NO2)-OH Structure

H-Arg(NO2)-OH

CAS#:2149-70-4

Literature: Justus Liebigs Annalen der Chemie, , vol. 642, p. 145 - 162

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H-Arg(NO2)-OH Structure

H-Arg(NO2)-OH

CAS#:2149-70-4

Literature: Chemische Berichte, , vol. 97, p. 3312 - 3316 Bulletin of the Chemical Society of Japan, , vol. 38, p. 1148 - 1157

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H-Arg(NO2)-OH Structure

H-Arg(NO2)-OH

CAS#:2149-70-4

Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 72, p. 489

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 Synonyms

(S)-2-Amino-5-(3-nitroguanidino)pentanoic acid
L-Ornithine, N-[(E)-imino(nitroamino)methyl]-
ARG(NO2)
L-NNA
N-ω-NITRO-L-ARGININE
L-NOARG
Nω-Nitro-L-arginine
(S)-2-Aminobut-3-enoic acid
H-Arg(NO2)-OH
L-Ornithine, N5-(imino(nitroamino)methyl)-
H-ARG(NO2)-OME
Nω-Nitro-L-arginine (L-NNA)
NG-nitro-L-arginine
EINECS 218-418-9
MFCD00007033
NG-NO2-L-ARG
L-NA,L-NNA
L-NA
L-NO2ARG
nitroarginine
Nomega-nitro-L-arginine
L-NNA N5-(Nitroamidino)-L-2,5-diaminopentanoic acid NG-NO2-L-Arg
L-NG-nitroarginine
N-(N-Nitrocarbamimidoyl)-L-ornithine
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