H-Arg(NO2)-OH structure
|
Common Name | H-Arg(NO2)-OH | ||
---|---|---|---|---|
CAS Number | 2149-70-4 | Molecular Weight | 219.199 | |
Density | 1.7±0.1 g/cm3 | Boiling Point | 462.4±55.0 °C at 760 mmHg | |
Molecular Formula | C6H13N5O4 | Melting Point | 257 °C (dec.)(lit.) | |
MSDS | Chinese USA | Flash Point | 233.5±31.5 °C |
Use of H-Arg(NO2)-OHNitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects. Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine. Nitroarginine is currently in clinical trials for treating patients with advanced solid tumors. |
Name | N'-Nitro-L-arginine |
---|---|
Synonym | More Synonyms |
Density | 1.7±0.1 g/cm3 |
---|---|
Boiling Point | 462.4±55.0 °C at 760 mmHg |
Melting Point | 257 °C (dec.)(lit.) |
Molecular Formula | C6H13N5O4 |
Molecular Weight | 219.199 |
Flash Point | 233.5±31.5 °C |
Exact Mass | 219.096756 |
PSA | 157.05000 |
LogP | -0.79 |
Vapour Pressure | 0.0±2.4 mmHg at 25°C |
Index of Refraction | 1.638 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
---|---|
Hazard Codes | Xn |
Risk Phrases | R22 |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
~% H-Arg(NO2)-OH CAS#:2149-70-4 |
Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 224, p. 40,43 |
~% H-Arg(NO2)-OH CAS#:2149-70-4 |
Literature: Justus Liebigs Annalen der Chemie, , vol. 642, p. 145 - 162 |
~% H-Arg(NO2)-OH CAS#:2149-70-4 |
Literature: Chemische Berichte, , vol. 97, p. 3312 - 3316 Bulletin of the Chemical Society of Japan, , vol. 38, p. 1148 - 1157 |
~% H-Arg(NO2)-OH CAS#:2149-70-4 |
Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 72, p. 489 |
Precursor 4 | |
---|---|
DownStream 10 | |
Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.
PLoS ONE 10 , e0134876, (2015) Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c... |
|
Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations.
Sci. Rep. 5 , 12298, (2015) Cancer immunotherapy has shown impressive results, but most patients do not respond. We hypothesized that the effector response in the tumour could be visualized as a complex network of interacting ge... |
|
Evidence for the gastric cytoprotective effect of centrally injected agmatine.
Brain Res. Bull. 108 , 51-9, (2014) Agmatine (decarboxylated arginine) exerts cytoprotective action in several tissues, such as in the brain, heart or kidneys, but there is still controversy over the effects of agmatine on the gastric m... |
(S)-2-Amino-5-(3-nitroguanidino)pentanoic acid |
L-Ornithine, N-[(E)-imino(nitroamino)methyl]- |
ARG(NO2) |
L-NNA |
N-ω-NITRO-L-ARGININE |
L-NOARG |
Nω-Nitro-L-arginine |
(S)-2-Aminobut-3-enoic acid |
H-Arg(NO2)-OH |
L-Ornithine, N5-(imino(nitroamino)methyl)- |
H-ARG(NO2)-OME |
Nω-Nitro-L-arginine (L-NNA) |
NG-nitro-L-arginine |
EINECS 218-418-9 |
MFCD00007033 |
NG-NO2-L-ARG |
L-NA,L-NNA |
L-NA |
L-NO2ARG |
nitroarginine |
Nomega-nitro-L-arginine |
L-NNA N5-(Nitroamidino)-L-2,5-diaminopentanoic acid NG-NO2-L-Arg |
L-NG-nitroarginine |
N-(N-Nitrocarbamimidoyl)-L-ornithine |