5-(Trifluoromethyl)uridine

Modify Date: 2024-01-02 12:02:53

5-(Trifluoromethyl)uridine Structure
5-(Trifluoromethyl)uridine structure
Common Name 5-(Trifluoromethyl)uridine
CAS Number 21618-67-7 Molecular Weight 312.20
Density 1.765g/cm3 Boiling Point N/A
Molecular Formula C10H11F3N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-(Trifluoromethyl)uridine


5-(Trifluoromethyl)uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 5-(trifluoromethyl)-uridine
Synonym More Synonyms

 5-(Trifluoromethyl)uridine Biological Activity

Description 5-(Trifluoromethyl)uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.765g/cm3
Molecular Formula C10H11F3N2O6
Molecular Weight 312.20
Exact Mass 312.05700
PSA 124.78000
Index of Refraction 1.563

 Synthetic Route

~23%

5-(Trifluoromethyl)uridine Structure

5-(Trifluoromet...

CAS#:21618-67-7

Literature: Tosoh Corporation; Tosoh F- Tech Inc.; SAGAMI CHEMICAL RESEARCH CENTER Patent: EP1947092 A1, 2008 ; Location in patent: Page/Page column 42 ;

~70%

5-(Trifluoromethyl)uridine Structure

5-(Trifluoromet...

CAS#:21618-67-7

Literature: Kobayashi, Yoshiro; Yamamoto, Kenjiro; Asai, Toyohira; Nakano, Masanori; Kumadaki, Itsumaro Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2755 - 2761

~%

5-(Trifluoromethyl)uridine Structure

5-(Trifluoromet...

CAS#:21618-67-7

Literature: Kobayashi, Yoshiro; Yamamoto, Kenjiro; Asai, Toyohira; Nakano, Masanori; Kumadaki, Itsumaro Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2755 - 2761

 Synonyms

5-trifluorouridine
500Mg,1g
5-trifluorothymidine
5-(trifluoromethyl)uridine