AR-C 118925XX

• 常用名: AR-C 118925XX
• 英文名: AR-C 118925XX
• CAS号: 216657-60-2
• 分子量: 537.592
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₈H₂₃N₇O₃S
• 熔点: N/A
• 闪点: N/A

AR-C 118925XX用途

ARC118925XX是一种选择性P2Y2受体拮抗剂。ARC118925XX抑制ATP诱导的IL-6产生和p38磷酸化。ARC118925XX还抑制博莱霉素(HY-108345)诱导的小鼠皮肤纤维化。ARC118925XX还抑制ATP诱导的肿瘤生长[1][2]。

AR-C 118925XX名称

• 英文名: AR-C118925XX

AR-C 118925XX生物活性

• 描述: ARC118925XX是一种选择性P2Y2受体拮抗剂。ARC118925XX抑制ATP诱导的IL-6产生和p38磷酸化。ARC118925XX还抑制博莱霉素(HY-108345)诱导的小鼠皮肤纤维化。ARC118925XX还抑制ATP诱导的肿瘤生长[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> P2Y受体
  研究领域 >> 炎症/免疫
• 靶点实验:

  P2Y2 Receptor

• 体内研究: 配置总成C118925XX(i.p.)抑制 博莱霉素对小鼠真皮厚度的增加[1]。
• 参考文献:

  [1]. Perera LMB, et al. The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor. J Invest Dermatol. 2019 Apr;139(4):890-899.

  [2]. Dong CR, et al. AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer. Carcinogenesis. 2022 Dec 5:bgac095.

AR-C 118925XX物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₈H₂₃N₇O₃S
• 分子量: 537.592
• 精确质量: 537.158325
• LogP: 4.78
• InChIKey: PVKNPGQAFNALOI-UHFFFAOYSA-N
• SMILES: Cc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1cn(Cc2ccc(C(=O)Nc3nn[nH]n3)o2)c(=O)[nH]c1=S
• 折射率: 1.756

AR-C 118925XX靶点实验

查看更多实验

实验名称：Human P2Y2 receptor (P2Y receptors) 来源：IUPHAR-DB 靶标：P2Y2 receptor (P2Y receptors) [Homo sapiens] External Id：324_Human

实验名称：Antagonist activity at human P2Y2R expressed in human 1321N1 cells assessed as inhibi... 来源：ChEMBL 靶标：P2Y purinoceptor 2 External Id：CHEMBL4121221

实验名称：Displacement of 2-((5-(7-chloro-2-((3-((2-(5-(3-(5,5-difluoro-7,9-dimethyl-5H-4lambda... 来源：ChEMBL 靶标：P2Y purinoceptor 2 External Id：CHEMBL5586080

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibi... 来源：ChEMBL 靶标：Uracil nucleotide/cysteinyl leukotriene receptor External Id：CHEMBL4722342

实验名称：Half life in rat administered via iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4047711

实验名称：Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibi... 来源：ChEMBL 靶标：Uracil nucleotide/cysteinyl leukotriene receptor External Id：CHEMBL4722343

实验名称：Bioavailability in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4047712

实验名称：Antagonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed a... 来源：ChEMBL 靶标：P2Y purinoceptor 2 External Id：CHEMBL4722340

实验名称：Clearance in rat administered via iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4047709

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AR-C 118925XX英文别名

• AR-C118925XX
• 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d][7]annulen-5-yl)-2-oxo-4-thioxo-3,4-dihydro-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furamide