5-O-Demethylnobiletin

Modify Date: 2024-01-10 22:42:12

5-O-Demethylnobiletin structure	Common Name	5-O-Demethylnobiletin
	CAS Number	2174-59-6	Molecular Weight	388.368
	Density	1.304±0.06 g/cm3	Boiling Point	601.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀O₈	Melting Point	145-146 ºC
	MSDS	N/A	Flash Point	213.9±25.0 °C

Use of 5-O-Demethylnobiletin

5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2].

Name	2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
Synonym	More Synonyms

Description	5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Neurological Disease
Target	IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1]
References	[1]. Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42. [2]. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63.

Density	1.304±0.06 g/cm3
Boiling Point	601.4±55.0 °C at 760 mmHg
Melting Point	145-146 ºC
Molecular Formula	C₂₀H₂₀O₈
Molecular Weight	388.368
Flash Point	213.9±25.0 °C
Exact Mass	388.115814
PSA	96.59000
LogP	2.10
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.583
Storage condition	2-8C
Water Solubility	Practically insoluble (0.058 g/L) (25 ºC)

HS Code	2914509090

Precursor 10
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DownStream 1
CAS#:478-01-3 Nobiletin

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%