Nobiletin

Modify Date: 2025-08-20 12:26:16

Nobiletin structure	Common Name	Nobiletin
	CAS Number	478-01-3	Molecular Weight	402.395
	Density	1.2±0.1 g/cm3	Boiling Point	587.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₂O₈	Melting Point	138 °C
	MSDS	Chinese USA	Flash Point	256.5±30.2 °C

Use of Nobiletin

Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities.

Name	nobiletin
Synonym	More Synonyms

Description	Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer Natural Products >> Flavonoids
References	[1]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Feb 12:1-6. [2]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21. [3]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Apr 29.

Description

Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities.

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Cancer

Natural Products >> Flavonoids

References

[1]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Feb 12:1-6.

[2]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21.

[3]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Apr 29.

Density	1.2±0.1 g/cm3
Boiling Point	587.9±50.0 °C at 760 mmHg
Melting Point	138 °C
Molecular Formula	C₂₁H₂₂O₈
Molecular Weight	402.395
Flash Point	256.5±30.2 °C
Exact Mass	402.131470
PSA	85.59000
LogP	2.48
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.558
InChIKey	MRIAQLRQZPPODS-UHFFFAOYSA-N
SMILES	COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)cc1OC
Storage condition	-20°C
Stability	Stable, but unstable if heated rapidly. Combustible. Incompatible with strong oxidizing agents, powdered aluminium, potassium.

Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36/37/39

Precursor 10
CAS#:654083-34-8 1-(2-hydroxy-3,... CAS#:683278-67-3 5,8-dihydroxy-6... CAS#:77-78-1 Dimethyl sulfate CAS#:3162-28-5 1-(2-hydroxy-3,...
CAS#:3535-37-3 veratroyl chloride CAS#:333347-81-2 (1H-benzo[d][1,... CAS#:634-36-6 dimethoxyanisole CAS#:21450-56-6 1,2,3,4-Tetrame...
CAS#:13909-75-6 1,2,3,4,5-penta... CAS#:5333-45-9 Benzene,1,2,3,5...
DownStream 10
CAS#:2798-20-1 Gardenin B CAS#:19103-54-9 Salvigenin CAS#:21763-80-4 5-Demethylsinensetin CAS#:479-90-3 Artemetin
CAS#:2174-59-6 5-O-Demethylnob... CAS#:1176-88-1 5-OH-HxMF CAS#:35154-55-3 Natsudaidain CAS#:1178-24-1 3,3',4',5,6,7,8...
CAS#:14786-40-4 1-(2,3,4,5,6-pe... CAS#:70460-32-1 4H-1-Benzopyran...

Name: Anti-melanogenic activity against human MNT-1 cells cocultured with 24 hrs compound p...
Source: ChEMBL
Target: MNT-1
External Id: CHEMBL5122091

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: Anti-melanogenic activity against human MNT-1 cells cocultured with 24 hrs compound p...
Source: ChEMBL
Target: MNT-1
External Id: CHEMBL5122092

Name: Anti-melanogenic activity against human MNT-1 cells cocultured with 24 hrs compound p...
Source: ChEMBL
Target: MNT-1
External Id: CHEMBL5122093

Name: Induction of resistance against Phytophthora citrophthora in Citrus (tangelo Nova) fr...
Source: ChEMBL
Target: Citrus
External Id: CHEMBL3083472

Name: Anti-melanogenic activity against human MNT-1 cells cocultured with 24 hrs compound p...
Source: ChEMBL
Target: MNT-1
External Id: CHEMBL5122094

Name: Induction of resistance against Phytophthora citrophthora in Citrus (tangelo Nova) fr...
Source: ChEMBL
Target: Citrus
External Id: CHEMBL3083473

Name: Anti-melanogenic activity against human MNT-1 cells cocultured with 24 hrs compound p...
Source: ChEMBL
Target: MNT-1
External Id: CHEMBL5122088

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Anti-melanogenic activity against human MNT-1 cells cocultured with 24 hrs compound p...
Source: ChEMBL
Target: MNT-1
External Id: CHEMBL5122089

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2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one

Flavone, 5,6,7,8,3',4'-hexamethoxy

Nobiletin,Hexamethoxyflavone

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

Nobiletin

3',4',5,6,7,8-hexamethoxy-flavone

5,6,7,8,3',4'-Hexamethoxyflavone

3',4',5,6,7,8-Hexamethoxyflavone

Hexamethoxyflavone

MFCD03273560

2-(3,4-dimethoxy-phenyl)-5,6,7,8-tetramethoxy-chromen-4-one

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nobiletin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Nobiletin
Price: ￥Inquiry/5mg
Purity: 97.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Nobiletin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Nobiletin
Price: ￥Inquiry/100mg ￥Inquiry/10mg ￥Inquiry/1g ￥Inquiry/250mg
Purity: 99.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Nobiletin
Price: ￥378.0/20mg
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

naturewill
China
Product Name: Nobiletin
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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Price: $66/10mM*1mLinDMSO

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Nobiletin

Use of Nobiletin

Names

Nobiletin Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

NobiletinBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.