Compound 919278

Modify Date: 2024-01-13 20:14:06

Compound 919278 Structure
Compound 919278 structure
Common Name Compound 919278
CAS Number 2189366-77-4 Molecular Weight 320.35
Density N/A Boiling Point N/A
Molecular Formula C18H16N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Compound 919278


LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α–induced p65 nuclear translocation[1].

 Names

Name LTβR-IN-1

 Compound 919278 Biological Activity

Description LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α–induced p65 nuclear translocation[1].
Related Catalog
Target

IC50: 10 μM (LTβR,p52 translocation)[1]

References

[1]. Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541).

 Chemical & Physical Properties

Molecular Formula C18H16N4O2
Molecular Weight 320.35