6-bromocoumarin-3-carboxylic acid
Modify Date: 2025-08-25 19:58:14
6-bromocoumarin-3-carboxylic acid structure
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Common Name | 6-bromocoumarin-3-carboxylic acid | ||
|---|---|---|---|---|
| CAS Number | 2199-87-3 | Molecular Weight | 269.04800 | |
| Density | 1.874g/cm3 | Boiling Point | 439ºC at 760mmHg | |
| Molecular Formula | C10H5BrO4 | Melting Point | 195-198 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 219.3ºC | |
Use of 6-bromocoumarin-3-carboxylic acidUBP608 is a potent N-Methyl-D-aspartate receptors (NMDARs) negative allosteric modulator. UBP608 has the potential for the research of neurological disorders[1]. |
| Name | 6-bromo-2-oxochromene-3-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | UBP608 is a potent N-Methyl-D-aspartate receptors (NMDARs) negative allosteric modulator. UBP608 has the potential for the research of neurological disorders[1]. |
|---|---|
| Related Catalog | |
| Target |
NMDA Receptor |
| In Vitro | UBP608 (100 µM) 显示出抑制活性，对 GluN1/GluN2A、GluN1/GluN2B、GluN1/GluN2C、GluN1/GluN2D 的抑制率分别为 89.3%、63.5%、56.1%、23.6%[1]。 |
| References |
| Density | 1.874g/cm3 |
|---|---|
| Boiling Point | 439ºC at 760mmHg |
| Melting Point | 195-198 °C(lit.) |
| Molecular Formula | C10H5BrO4 |
| Molecular Weight | 269.04800 |
| Flash Point | 219.3ºC |
| Exact Mass | 267.93700 |
| PSA | 67.51000 |
| LogP | 2.25370 |
| Vapour Pressure | 1.76E-08mmHg at 25°C |
| InChIKey | XFQHPAXNKDYMOX-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cc2cc(Br)ccc2oc1=O |
| Storage condition | room temp |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932209090 |
| Precursor 9 | |
|---|---|
| DownStream 1 | |
CAS#:2199-90-8
CAS#:2033-24-1
CAS#:1761-61-1
CAS#:90-02-8
CAS#:25016-01-7
CAS#:89228-64-8
CAS#:82486-43-9
CAS#:76693-35-1
CAS#:141-82-2
CAS#:2199-94-2| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Name: Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensit...
Source: ChEMBL
Target: G-protein coupled receptor 35
External Id: CHEMBL4042614
|
|
Name: Agonist activity at GPR35 in human HT-29 cells in presence of antagonist ML-145 by DM...
Source: ChEMBL
Target: G-protein coupled receptor 35
External Id: CHEMBL4042615
|
|
Name: Agonist activity at GPR35 in human HT-29 cells by DMR assay
Source: ChEMBL
Target: G-protein coupled receptor 35
External Id: CHEMBL4042613
|
|
Name: Selectivity ratio of IC50 for NTD-deleted GluN1/NTD-deleted GluN2D receptor (unknown ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2343346
|
|
Name: Cell-based high throughput primary assay to identify activators of GPR151
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id: GPR151_PHUNTER_AG_LUMI_1536_1X%ACT
|
|
Name: Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu...
Source: 15621
Target: G protein-activated inward rectifier potassium channel 2
External Id: VANDERBILT_HTS_GIRK2_MPD
|
|
Name: Alphascreen assay for small molecules abrogating mHTT-CaM Interaction
Source: 24983
Target: Huntingtin
External Id: KUHTS-Muma KU-CaM-Htt INH-01
|
|
Name: Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenop...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2D
External Id: CHEMBL4309007
|
|
Name: Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenop...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2C
External Id: CHEMBL4309006
|
|
Name: AlphaScreen-based biochemical high throughput primary assay to identify activators of...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: FBW7_ACT_ALPHA_1536_1X%ACT PRUN
|
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| 6-Bromocoumarin-3-carboxylic acid |
| 6-Bromocoumarin-3-carboxylicAcid |