BCL6-IN-8
Modify Date: 2025-09-29 19:41:56
BCL6-IN-8 structure
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Common Name | BCL6-IN-8 | ||
|---|---|---|---|---|
| CAS Number | 2204272-40-0 | Molecular Weight | 666.553 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H37Cl2N5O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BCL6-IN-8BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface; shows intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell growth inhibition; BCL6-i is a cell-active chemical probe with the most potent BCL6 inhibitory activity reported to date. |
| Name | BCL6-IN-8 |
|---|
| Description | BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface; shows intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell growth inhibition; BCL6-i is a cell-active chemical probe with the most potent BCL6 inhibitory activity reported to date. |
|---|---|
| References | References 1. Sameshima T, et al. Biochemistry. 2018 Feb 7. doi: 10.1021/acs.biochem.7b00732. View Related Products by Target Bcl-2 |
| Molecular Formula | C30H37Cl2N5O8 |
|---|---|
| Molecular Weight | 666.553 |
| InChIKey | QQSHEMQKLUMPQB-RUZDIDTESA-N |
| SMILES | CCC(=O)NCCN1C(=O)C(CCCCNC(=O)CCl)Oc2cc(Nc3cc(OC4CCOCC4)c([N+](=O)[O-])cc3Cl)ccc21 |