QCA570

Modify Date: 2025-09-02 19:49:00

QCA570 Structure
QCA570 structure
 Common Name QCA570
CAS Number 2207569-08-0 Molecular Weight 695.798
Density N/A Boiling Point N/A
Molecular Formula C39H33N7O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of QCA570


QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.

 Names

Name QCA570

 QCA570 Biological Activity

Description QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.
Related Catalog
Target

BRD4 BD1:10 nM (IC50)

In Vitro QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date[1].
Animal Admin Mice[1] Female SCID mice bearing RS4;11 xenograft tumors were dosed with a single intravenous dose of QCA570 (compound 35) at 5 mg/kg[1].
References

[1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

 Chemical & Physical Properties

Molecular Formula C39H33N7O4S
Molecular Weight 695.798

 Safety Information

Hazard Codes Xi
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Chemsrc provides QCA570(CAS#:2207569-08-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of QCA570 are included as well.>> amp version: QCA570

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