Top Suppliers:I want be here


2207569-08-0

2207569-08-0 structure
2207569-08-0 structure
  • Name: QCA570
  • Chemical Name: QCA570
  • CAS Number: 2207569-08-0
  • Molecular Formula: C39H33N7O4S
  • Molecular Weight: 695.798
  • Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
  • Create Date: 2018-11-18 21:40:28
  • Modify Date: 2025-09-02 19:49:00
  • QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.

Name QCA570
Description QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.
Related Catalog
Target

BRD4 BD1:10 nM (IC50)

In Vitro QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date[1].
Animal Admin Mice[1] Female SCID mice bearing RS4;11 xenograft tumors were dosed with a single intravenous dose of QCA570 (compound 35) at 5 mg/kg[1].
References

[1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

Molecular Formula C39H33N7O4S
Molecular Weight 695.798
Hazard Codes Xi
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.