PDGFRα kinase inhibitor 1

Modify Date: 2024-01-09 19:27:58

PDGFRα kinase inhibitor 1 Structure
PDGFRα kinase inhibitor 1 structure
Common Name PDGFRα kinase inhibitor 1
CAS Number 2209053-93-8 Molecular Weight 586.69
Density N/A Boiling Point N/A
Molecular Formula C34H34N8O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PDGFRα kinase inhibitor 1


PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].

 Names

Name PDGFRα kinase inhibitor 1

 PDGFRα kinase inhibitor 1 Biological Activity

Description PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].
Related Catalog
Target

PDGFRα:132 nM (IC50)

PDGFRβ:6115 nM (IC50)

In Vitro PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1].
References

[1]. Wang Q, et al. Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384.

 Chemical & Physical Properties

Molecular Formula C34H34N8O2
Molecular Weight 586.69
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