LIMK1 and 2 dual inhibitor

Modify Date: 2024-01-10 12:39:55

LIMK1 and 2 dual inhibitor Structure
LIMK1 and 2 dual inhibitor structure
Common Name LIMK1 and 2 dual inhibitor
CAS Number 2215049-71-9 Molecular Weight 610.63
Density N/A Boiling Point N/A
Molecular Formula C28H21F3N6O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LIMK1 and 2 dual inhibitor


LIMK1 and 2 dual inhibitor is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM); inhibits p-c-ofilin at Ser3 site, suppresses cell proliferation of MV-411 cell of with IC50 of 1-5 uM.

 Names

Name LIMK1 and 2 dual inhibitor

 LIMK1 and 2 dual inhibitor Biological Activity

Description LIMK1 and 2 dual inhibitor is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM); inhibits p-c-ofilin at Ser3 site, suppresses cell proliferation of MV-411 cell of with IC50 of 1-5 uM.
References References 1. US Patent WO 2018055097. View Related Products by Target LIM Kinase (LIMK)

 Chemical & Physical Properties

Molecular Formula C28H21F3N6O3S2
Molecular Weight 610.63