300809-71-6
300809-71-6 structure
- Name: KRAS inhibitor-9
- Chemical Name: 4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline
- CAS Number: 300809-71-6
- Molecular Formula: C13H9ClN2S2
- Molecular Weight: 292.807
- Create Date: 2021-01-09 19:44:58
- Modify Date: 2024-01-02 17:37:07
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KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells.
| Name | 4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline |
|---|---|
| Synonyms |
4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline
Benzenamine, 4-(2-benzothiazolylthio)-3-chloro- MFCD00227023 4-(Benzothiazol-2-ylsulfanyl)-3-chloro-phenylamine |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 492.4±55.0 °C at 760 mmHg |
| Molecular Formula | C13H9ClN2S2 |
| Molecular Weight | 292.807 |
| Flash Point | 251.6±31.5 °C |
| Exact Mass | 291.989563 |
| LogP | 4.85 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.772 |
| Hazard Codes | Xi |
|---|