22(R)-HYDROXYCHOLESTEROL
22(R)-HYDROXYCHOLESTEROL structure
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Common Name | 22(R)-HYDROXYCHOLESTEROL | ||
|---|---|---|---|---|
| CAS Number | 22348-64-7 | Molecular Weight | 402.65300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H46O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of 22(R)-HYDROXYCHOLESTEROLCholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2]. |
| Name | (22S)-22-hydroxycholesterol |
|---|---|
| Synonym | More Synonyms |
| Description | Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2]. |
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| Related Catalog | |
| In Vitro | Cholest-5-ene-3ß,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) 对 U937 细胞磷脂酰丝氨酸外化、线粒体跨膜电位、细胞对碘化丙啶的通透性和细胞核形态变化无影响[1]。 |
| In Vivo | Cholest-5-ene-3ß,22(S)-diol (30 mg/kg; 口服; 在加饮食中，共处理 3 周) 减少体重增加，消除高脂饮食引起的血清中三酰甘油 (TAG) 水平的增加[2]。 在大鼠中的药代动力学分析[2] Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) AUCt (ng·h/mL) AUC (ng·h/mL) T1/2 (h) Extent of tritium exchange (%) i.v. 50 22.4 0.08 174 195 8.1 2.8 p.o. 50 7.5 4 95.2 104 6.4 1.2 Animal Model: Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)[2] Dosage: 30 mg/kg/day Administration: Oral gavage; 3 weeks consecutively Result: Decreased body weight gain significantly after 1 week treatment. Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment. |
| References |
| Molecular Formula | C27H46O2 |
|---|---|
| Molecular Weight | 402.65300 |
| Exact Mass | 402.35000 |
| PSA | 40.46000 |
| LogP | 6.35950 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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| 22S-hydroxycholesterol |
| 22(R)-HYDROXYCHOLESTEROL |
| beta2-Solamargine |
| 22(S)-Hydroxycholesterol |