PLpro inhibitor
Modify Date: 2024-01-03 09:00:12
PLpro inhibitor structure
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Common Name | PLpro inhibitor | ||
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| CAS Number | 1093070-14-4 | Molecular Weight | 346.42200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H22N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PLpro inhibitorPLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.IC50 Value: 2.6 uM [1]Target: PLpro; SARS-CoVin vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].in vivo: |
| Name | 5-acetamido-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide |
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| Synonym | More Synonyms |
| Description | PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.IC50 Value: 2.6 uM [1]Target: PLpro; SARS-CoVin vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].in vivo: |
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| Related Catalog | |
| References |
| Molecular Formula | C22H22N2O2 |
|---|---|
| Molecular Weight | 346.42200 |
| Exact Mass | 346.16800 |
| PSA | 65.18000 |
| LogP | 5.30340 |
| Storage condition | 2-8℃ |
| 5-acetamido-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide |
| PLpro inhibitor |
| 5-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide |
| I06-1404 |
| 5-N-Acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide |