2'-Deoxyinosine

Modify Date: 2024-01-02 12:36:49

2'-Deoxyinosine Structure
2'-Deoxyinosine structure
 Common Name 2'-Deoxyinosine
CAS Number 890-38-0 Molecular Weight 252.227
Density 1.9±0.1 g/cm3 Boiling Point 620.6±65.0 °C at 760 mmHg
Molecular Formula C10H12N4O4 Melting Point 250 °C
MSDS USA Flash Point 329.1±34.3 °C

 Use of 2'-Deoxyinosine


2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.

 Names

Name 2ʼ-deoxyinosine
Synonym More Synonyms

 2'-Deoxyinosine Biological Activity

Description 2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.
Related Catalog
Target

Human Endogenous Metabolite
In Vitro In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals[1].
Cell Assay Various amounts of cells, ranging from 1,000 to 900,000, suspended in 3 mL of standard medium, are plated in 35-mm dishes and incubated in the absence (control) and in the presence of both 1 μM dCF and 0.1 mM dAdo, as indicated in each experiment. dCf was added to the standard medium 30 min before 2’-deoxyadenosine (dAdo). Furthermore, an incubation is performed in which 0.1 mM 2’-deoxyadenosine alone is added to the standard medium. After 4 days of incubation, the standard medium is withdrawn, then 0.5 mL of 0.025% trypsin containing 0.02% EDTA is added and kept for few minutes at 37°C. The cells are collected, diluted in an appropriate volume of standard medium, and counted[1].
References

[1]. Bemi V, et al. Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. Int J Cancer. 1998 Mar 2;75(5):713-20.

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 620.6±65.0 °C at 760 mmHg
Melting Point 250 °C
Molecular Formula C10H12N4O4
Molecular Weight 252.227
Flash Point 329.1±34.3 °C
Exact Mass 252.085861
PSA 113.26000
LogP -1.43
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.837
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn,Xi
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles41

More Articles
Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1356 , 197-210, (2014)

Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved u...
Preparation and evaluation of a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid.

J. Chromatogr. A. 1375 , 101-9, (2014)

To develop a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid, a new ionic liquid monomer was synthesized from 1-vinylimidazole and pentafluorobenzyl bromide....
Comparative characterization of nucleotides, nucleosides and nucleobases in Abelmoschus manihot roots, stems, leaves and flowers during different growth periods by UPLC-TQ-MS/MS.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1006 , 130-7, (2015)

Nucleotides, nucleosides and nucleobases have been proven as important bioactive compounds related to many physiological processes. Abelmoschus manihot (L.) Medicus from the family of Malvaceae is an ...

 Synonyms

INOSINE, 2'-DEOXY-
Inosine,2'-deoxy
EINECS 212-964-1
9H-Purin-6-ol, 9-(2-deoxy-β-D-erythro-pentofuranosyl)-
2'-Deoxyinosine
9-(2-deoxy-b-D-erythro-pentofuranosyl)-Hypoxanthine
9-(2-deoxy-β-D-erythro-pentofuranosyl)-Hypoxanthine
9-(2-Deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one
9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol
Deoxyinosine
(-)-2'-Deoxyinosine
d-Ino
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE TRISODIUM SALT,DGTP
MFCD00005762
Top Suppliers:I want be here

Get all suppliers and price by the below link:

2'-Deoxyinosine suppliers

Price: ￥312/5g

Reference only. check more 2'-Deoxyinosine price

Related Compounds: More...
(-)-2'-deoxyinosine
179112-93-7
2-aza-2'-deoxyinosine
56220-50-9
6-thio-2'-deoxyinosine
2239-64-7
2-bromo-2'-deoxyinosine
123994-87-6
[1-15N]-2'-Deoxyinosine
156517-75-8
2-fluoro-2'-deoxyinosine
133931-92-7
2'-amino-2'-deoxyinosine
75763-51-8
2'-Amino-2'-deoxyinosine
19889-76-0
4'-Azido-2'-deoxyinosine
130108-77-9
Chemsrc provides 2'-Deoxyinosine(CAS#:890-38-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 2'-Deoxyinosine are included as well.>> amp version: 2'-Deoxyinosine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved