SMS2-IN-2

Modify Date: 2024-01-06 16:27:04

SMS2-IN-2 structure	Common Name	SMS2-IN-2
	CAS Number	2241838-28-6	Molecular Weight	369.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₃ClFN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SMS2-IN-2

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].

Name	SMS2-IN-2

Description	SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 100 nM (SMS2), 56 μM (SMS1)[1]
In Vivo	SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice[1]. Animal Model: Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)[1] Dosage: 20, 50 mg/kg/day Administration: P.O. daily for 6 weeks Result: Significantly reduced IL-6 and insulin levels.
References	[1]. Mo M, et al. Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem. 2018 Sep 27;61(18):8241-8254.

Molecular Formula	C₁₉H₁₃ClFN₃O₂
Molecular Weight	369.78