BIS(7)-TACRINE
Modify Date: 2024-01-10 18:35:25
BIS(7)-TACRINE structure
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Common Name | BIS(7)-TACRINE | ||
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| CAS Number | 224445-12-9 | Molecular Weight | 565.619 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H42Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BIS(7)-TACRINEBis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease [1][2][3]. |
| Name | N,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine,dihydrochloride |
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| Synonym | More Synonyms |
| Description | Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease [1][2][3]. |
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| Related Catalog | |
| References |
| Molecular Formula | C33H42Cl2N4 |
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| Molecular Weight | 565.619 |
| Exact Mass | 564.278625 |
| PSA | 49.84000 |
| LogP | 9.76510 |
| Hazard Codes | T: Toxic; |
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| Risk Phrases | 25-36/37/38 |
| Safety Phrases | 26-36-45 |
| RIDADR | UN 2811 6.1/PG 3 |
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Synthesis of alkylene linked bis-THA and linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase. Pang, et al.
J. Chem. Soc. Perkin Trans. I , 171, (1997)
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Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.
J. Biol. Chem. 271 , 23646, (1996) We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand doc... |
| N,N'-Di(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine dihydrochloride |
| 9-Amino-1,2,3,4-tetrahydroacridine bis 1,7-heptylene dihydrochloride |
| Tacrine-Based Inhibitor 2f |
| heptylene-bis(tacrine) dihydrochloride heptylene-bis(THA) dihydrochloride |
| 1,7-Heptanediamine, N,N-bis(1,2,3,4-tetrahydro-9-acridinyl)-, hydrochloride (1:2) |