bis(7)-Tacrine结构式
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常用名 | bis(7)-Tacrine | 英文名 | BIS(7)-TACRINE |
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CAS号 | 224445-12-9 | 分子量 | 565.619 | |
密度 | N/A | 沸点 | N/A | |
分子式 | C33H42Cl2N4 | 熔点 | N/A | |
MSDS | N/A | 闪点 | N/A |
bis(7)-Tacrine用途双(7)-盐酸他克林是从他克林衍生的二聚体乙酰胆碱酯酶抑制剂。双(7)-盐酸他克林通过阻断NMDA受体防止谷氨酸诱导的神经元凋亡。双(7)-盐酸他克林是一种有效的GABA受体拮抗剂。双(7)-盐酸他克林具有研究阿尔茨海默病的潜力[1][2][3]。 |
中文名 | bis(7)-Tacrine |
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英文名 | N,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine,dihydrochloride |
英文别名 | 更多 |
描述 | 双(7)-盐酸他克林是从他克林衍生的二聚体乙酰胆碱酯酶抑制剂。双(7)-盐酸他克林通过阻断NMDA受体防止谷氨酸诱导的神经元凋亡。双(7)-盐酸他克林是一种有效的GABA受体拮抗剂。双(7)-盐酸他克林具有研究阿尔茨海默病的潜力[1][2][3]。 |
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相关类别 | |
参考文献 |
分子式 | C33H42Cl2N4 |
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分子量 | 565.619 |
精确质量 | 564.278625 |
PSA | 49.84000 |
LogP | 9.76510 |
储存条件 | -20°C,密闭,干燥 |
危害码 (欧洲) | T: Toxic; |
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风险声明 (欧洲) | 25-36/37/38 |
安全声明 (欧洲) | 26-36-45 |
危险品运输编码 | UN 2811 6.1/PG 3 |
Synthesis of alkylene linked bis-THA and linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase. Pang, et al.
J. Chem. Soc. Perkin Trans. I , 171, (1997)
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Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.
J. Biol. Chem. 271 , 23646, (1996) We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand doc... |
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