PROTAC BTK Degrader-2

Modify Date: 2025-08-26 17:44:58

PROTAC BTK Degrader-2 structure	Common Name	PROTAC BTK Degrader-2
	CAS Number	2250382-66-0	Molecular Weight	976.97
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₇H₅₄F₂N₈O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PROTAC BTK Degrader-2

PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels[1].

Name	PROTAC BTK Degrader-2

Description	PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> PROTAC >> PROTAC
In Vitro	PROTAC BTK Degrader-2 (compound 10; 1 µM; 24 h; Ramos 细胞) 促进培养细胞中的 BTK 降解[1]。
In Vivo	PROTAC BTK Degrader-2 (compound 10; 0-175 mg/kg; s.c.) 在大鼠体内选择性降解 BTK[1]。 Animal Model: male Wistar Han rats[1] Dosage: 0, 0.35, 35, and 175 mg/kg Administration: subcutaneous injection Result: Degraded BTK in a dose-dependent and tissue-biased manner.
References	[1]. Zorba A, et, al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.

Molecular Formula	C₄₇H₅₄F₂N₈O₁₃
Molecular Weight	976.97

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